Naturally Occurring Follicle-Stimulating Hormone Glycosylation Variants

Naturally Occurring Follicle-Stimulating Hormone Glycosylation Variants

Follicle-stimulating hormone (FSH) is a member of the glycoprotein hormone family, which is a subfamily of the cystine knot growth factor superfamily [1,2]. The glycoprotein hormones are composed of heterodimeric glycoprotein subunits, a common α-subunit, and a hormone-specific β-subunit. While the α-subunit primary structure is identical for all glycoprotein hormones within the same species, t...

N , 0 - Diacetylserinel a - Melanocyte - stimulating Hormone , a Naturally Occurring

When aqueous extract of bovine pituitary gland was fractionated by high pressure liquid chromatography (HPLC), the effluent contained a prominent peak of melanotropic activity which did not correspond to amelanocyte-stimulating hormone (MSH), /?-MSH, adrenocorticotropic hormone, or p lipotropin. The novel factor (labeled “post-a-MSH”), responsible for onethird of the melanotropic activity in th...

Follicle-stimulating hormone

Bioactive Follicle-Stimulating Hormone

Specific and sensitive in vitro bioassays suitable for measurement of follicle-stimulating hormone (FSH) in small quantities of serum and urine have recently been validated. Comparisons of bioassay (B-FSH) potencies with immunoassay (I-FSH) estimates and chromatofocusing patterns have facilitated new discoveries regarding the regulation of FSH biosynthesis, storage, secretion, serum concentrati...

Studies on the relative in-vitro biological potency of the naturally-occurring isoforms of intrapituitary follicle stimulating hormone.

In the present study, we analysed and compared the relative in-vitro biological activity of the various intrapituitary human follicle stimulating hormone (FSH) isoforms employing two different bioassay systems. FSH was fractionated by chromatofocusing (pH range 7.10 to < 3.80) and the several isoforms isolated were quantified at multiple dose levels by three highly specific immunoassay systems:...